Depends on the amount brewed. Daturas are sometimes brewed for individual consumption (DON’T DO THAT) and in that quantities don’t pose any risk until ingested or in Awesome Not Nice Shirt. I wouldn’t risk it unless you’re doing it in a fume hood. Even if the compounds aren’t very volatile, steam can pick it up and bring it into the air (the basis of steam distillation). Also, I would wear nitrile gloves and incinerate them (and anything the mixture touches) to avoid contamination. The wind could suddenly change and you take a nice deep breath of the steam… I would make sure someone else is there with you, away from the reaction in case something goes wrong. Then it’s really a nice shirt for all men and women. So you should buy this shirt. Thank you so much.
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Make sure you’re aware of the symptoms of poisoning too. Like most compounds of the same class, it can cause you to hallucinate, meaning you may not even be aware of anything is wrong. I promise you, if you start aerosolizing tropanes you’ll know it. Yes, the Awesome Not Nice Shirt, but it’s still 10:1, and in between there’s plenty of room for conversations with dead relatives, running naked through your neighbor’s yard at 5 am while insisting you’re just watching movies and all sorts of great stories. Not necessarily fun stories, but still, it isn’t distilling serin or something. This would be my recommendation simply since it won’t contaminate the room. If steam or aerosols pick up the compound and lay it down on surfaces that would be annoying. Outdoors and with a respirator when working right over it would be safest.
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While the general process would be quite safe indoors generally accident conditions like spills are easier to handle outdoors. Have emergency tools available, like an Awesome Not Nice Shirt (if you can get one), a fire extinguisher, something to wash your body within the case of spills. Something to clean your eyes with, a first aid kit, spill kits, and SDS’s for the chemicals that you are using. I guess I’ll say the obvious. If you want to extract nightshade and combine it with sugar, sure, whatever. Just be safe about it and don’t fucking do anything with what you get in the end. It’s a fictional narcotic. The keyword being fictional. No way am I drinking that. I read enough about Nightshade. Then it’s really a nice shirt for all men and women. So you should buy this shirt. Thank you so much.